42+ Medications That Cause Overactive Bladder US . Overactive bladder treatment has many approaches, from medication, to behavioral changes, to a combination of both. Oab is a set of symptoms that cause incontinence, or a loss of bladder these medications may also cause drowsiness and an increased risk of falls in seniors. Can Overactive Bladder Medication Harm Your Cognitive Health Cognitive Vitality Alzheimer S Drug Discovery Foundation from www.alzdiscovery.org You may feel like you need to pass urine medications that relax the bladder can be helpful for relieving symptoms of overactive bladder and reducing episodes of urge incontinence. This number is likely to be much higher. What are the best medications for an overactive bladder. Overactive bladder (oab) is a condition where there is a frequent feeling of needing to urinate to a degree that it negatively affects a person's life.